Molecular Biology of the Cell

"Throughout the book, emphasis is placed not just on what 'we know' but also on 'how we know' and 'what remains to be discovered'- important for engaging and enthusing students....A quarter of a century after the first edition revolutionised cell biology textbooks, the new edition is as fresh, comprehensive and above all, as readable as ever....Like its predecessors, this is a superb textbook for advanced undergraduate and postgraduate students." -British Society for Developmental Biology Newsletter, Summer 2008, Vol. 29, No. 1 "Professors, lecturers, and instructors will find the fifth edition of the book Molecular Biology of the Cell and its accompanying Problems Book to be an excellent choice for guiding their students through the maze of the cell's molecular structures and biochemical processes....With countless colorful illustrations and a large number of photographs and tables, reading the text becomes not only an educational experience, but also a highly enjoyable one for those students who wish to discover the inner workings of the magnificent cellular machine....Educators will also find the DVD-ROM to be a rich electronic resource when compiling their lectures....No less important is the Problems Book, which contains numerous exercises and questions that are an integral part of the learning process, and that teachers, instructors, and students are sure to appreciate." The Quarterly Review of Biology, September 2008, Volume 83, Number 3

Bruce Alberts received his PhD from Harvard University and is the Chancellor's Leadership Chair in Biochemistry and Biophysics for Science and Education, University of California, San Francisco. He was the editor in chief of Science magazine from 2008 until 2013, and for 12 years he served as president of the U.S. National Academy of Sciences (1993-2005). Alexander Johnson received his PhD from Harvard University and is a professor of microbiology and immunology at the University of California, San Francisco. He is a member of the National Academy of Sciences. Julian Lewis received his DPhil from the University of Oxford and was a Principal Scientist at the London Research Institute of Cancer Research UK. David Morgan received his PhD from the University of California, San Francisco, and is a professor in the Department of Physiology as well as the vice dean for research for the School of Medicine. Dave is a fellow of the Royal Society of London. Martin Raff received his MD from McGill University and is emeritus professor of biology at the Medical Research Council Laboratory for Molecular Cell Biology at University College London. He is a foreign member of the National Academy of Sciences. Keith Roberts received his PhD from the University of Cambridge and was deputy director of the John Innes Centre, Norwich. He is emeritus professor at the University of East Anglia. Keith was recipient of the Order of British Empire for his service to sciences. Peter Walter received his PhD from the Rockefeller University in New York, is a professor in the Department of Biochemistry and Biophysics at the University of California, San Francisco, and is an investigator at the Howard Hughes Medical Institute. He is a member of the National Academy of Sciences.

INTRODUCTION TO THE CELL 1. Cells and Genomes 2. Cell Chemistry and Bioenergetics 3. Proteins BASIC GENETIC MECHANISMS 4. DNA, Chromosomes, and Genomes 5. DNA Replication, Repair, and Recombination 6. How Cells Read the Genome: From DNA to Protein 7. Control of Gene Expression WAYS OF WORKING WITH CELLS 8. Analyzing Cells, Molecules, and Systems 9. Visualizing Cells INTERNAL ORGANIZATION OF THE CELL 10. Membrane Structure 11. Membrane Transport of Small Molecules and the Electrical Properties of Membranes 12. Intracellular Compartments and Protein Sorting 13. Intracellular Membrane Traffic 14. Energy Conversion: Mitochondria and Chloroplasts 15. Cell Signaling 16. The Cytoskeleton 17. The Cell Cycle 18. Cell Death CELLS IN THEIR SOCIAL CONTEXT 19. Cell Junctions and the Extracellular Matrix 20. Cancer 21. Development of Multicellular Organisms 22. Stem Cells and Tissue Renewal 23. Pathogens and Infection 24. The Innate and Adaptive Immune Systems