Offering a comprehensive overview, this book systematically characterizes various transporters involved in drug elimination and resistance. It focuses on transport across those physiological barriers relevant for drug uptake, distribution and excretion. It is suitable for those working with antibiot[...]

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two t[...]

As every chemist knows, there is a direct (if complex) relationship between the molecular structure of a compound and its chemical behavior. Predicting such behavior is possible by an abstract representation of its structure in terms of chemical similarity parameters, so-called 'descriptors'. These [...]

A reference on methods to generate pharmacokinetic and safety profiles of drug candidates, and how they must be balanced against one other for the best selection of candidates for further development. It presents an introduction to the necessities of filtering and risk assessment of potential new dr[...]